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Pfizer, DxS To Develop Brain Tumor Companion Diagnostic Kit

Published: 05-Feb-2010

Pfizer and DxS, a wholly-owned subsidiary of Qiagen, have collaborated to develop a companion diagnostic test kit for PF-04948568 (CDX-110), an immunotherapy vaccine in development for the treatment of glioblastoma multiforme (GBM).

The Qiagen assay is designed to identify those patients whose tumors express the EGFRvIII mutation, allowing for the possibility of more targeted and personalised treatment.

The company said that the EGFRvIII companion diagnostic will be developed and manufactured at Qiagen’s Center of Excellence for Companion Diagnostics in Manchester. The diagnostic will be a real-time PCR assay used to detect EGFRvIII RNA in tumor tissue. The assay is designed to offer a simple workflow, which supports its clinical utility in routine mutation testing.

Stephen Little, vice president of personalized healthcare at Qiagen, said: “We are pleased to have signed this agreement with Pfizer, as it is another important step toward the realisation of personalised medicine. Qiagen is aligned to deliver companion diagnostics to our pharmaceutical partners and this deal is further evidence of our commitment to develop our scientific and operational capabilities to help select the right patient for the right medicine.”

Garry Nicholson, president and general manager of oncology business unit at Pfizer, said: “We look forward to collaborating with Qiagen's DxS unit in the development of this important diagnostic tool that could potentially help physicians better define the most appropriate treatment for patients who suffer from glioblastoma multiforme.”

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