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Biocoat - Lubricious Hydrophilic Coatings for Medical Devices

Lubricious Hydrophilic Coatings for Medical Devices

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Biocoat, Inc. develops and licenses biomaterial coatings for medical devices that are custom engineered to meet client design parameters. Its speciality is supplying lubricious hydrophilic coatings for medical devices.

Based on hyaluronic acid, a natural lubricant found in all body tissues, HYDAK® hydrophilic coatings for medical devices are lubricious, abrasion resistant, non-thrombogenic, and biocompatible. Suitable for coating vascular catheters, guide wires and other medical devices, they can be applied to a wide range of polymeric and metallic substrates.

The HYDAK® Process: Immobilised hyaluronan coatings technology

HYDAK is Biocoat's registered trademark for its immobilised hyaluronan coatings technology. Application of the HYDAK Coatings is a relatively simple process using conventional coating equipment and curing ovens. Usually coatings are applied by dip-coating. HYDAK Coatings can be used on both inside and outside surfaces and on most commonly used polymers and metals.

HYDAK advantages

Exceptionally hydrophilic
Lubricious when wet, preventing trauma and tissue abrasion
Abrasion resistant
Very thin, flexible coatings can be applied
Biocompatible
Non-thrombogenic
Inhibits adhesion of platelets, proteins and microorganisms
Carrier for bioactive substances to make
Anti-bacterial surfaces
Anti-thrombogenic surfaces

HYDAK-coated surfaces exhibit a marked reduction or absence of:

Adsorbed platelets
Proteins
Bacteria
Acute thrombus formation

Biocompatibile hyaluronan-modified surfaces

As one might expect for a material that is ubiquitous in the body, the biocompatibility of hyaluronan-modified surfaces has been well-established and confirmed by in vitro and in vivo tests including:

Cytotoxicity
Hemolysis
Acute systemic toxicity
Intracutaneous toxicity
Muscle implantation
Dermal irritation
Genotoxicity

Tailoring biocompatible surfaces

The HYDAK system of coatings affords great flexibility in tailoring biocompatible surfaces to the requirements of medical device applications.

Physical properties are readily adapted to meet the design criteria of medical device applications:

Thickness
Wettability
Lubricity
Flexibility
Abrasion resistance
Storage stability

Hydrophilic coatings and biocompatible surfaces

The HYDAK system of coatings is versatile and has applications in a wide variety of medical fields. Medical devices on the market already employ this technology, and new types of devices that require hydrophilic coatings and biocompatible surfaces are constantly arising. Possible applications include: